Corporate Overview

Who We Are

Skilled medicinal chemists
Conception and synthesis of new analogs for lead optimization, SAR expansion, hit to lead transition.
Extensive background in synthetic chemistry and working at the interface between chemistry and pharmacology, toxicology, drug metabolism, pharmacokinetics.
Skilled process chemists
Innovative scalable solutions
Stable label synthesis (¹³C, ¹⁵N, ²H)
A business designed from a customer’s perspective

Strengths

Provide you with a turn-key, world class chemistry department.
Understand and treat intellectual property with the mission critical importance it deserves
Provide you with a chemistry solution that does not need constant oversight.
Provide novel and innovative solutions (patentable) to therapeutic programs.
Team members that have spent decades working on therapeutic program teams.
Implement communication strategies designed around your needs.

Our Staff

Our chemists and senior advisors have a total of over 1000 publications and patents and have had key roles in the invention and development of several marketed drugs.
Kalexsyn currently has 34 employees. 24 medicinal chemists at the bench. ~1:1 ratio of Ph.D. to MS/BS. Currently recruiting with a goal of an additional 3 new scientists by 1Q 2010.

Early API Capabilities

Under direction of Dr. Peter Wuts
- Author of Protective Groups in Organic Synthesis

We Understand and Address Your Concerns

We realize you have other duties and minimize the time you need to manage our collaboration through complete communication and access to data.
We will meet or exceed your in-house quality standards.
We have the expertise to solve problems in conjunction with you.
We provide timelines that are aggressive yet obtainable.
All issues regarding your project are provided to you as soon as available.
We don’t conduct in-house research. You get our best scientists and our full attention. Your CRO shouldn’t compete against you.

Full Analytical Capabilities

Cheminformatics Capabilities

Symyx Enterprise Software
- Electronic Notebook
- Reaction Database
SciFinder
- Unlimited searching for every chemist
Access to journals
- Access to reprints of all journals through reprint providers.
- Access to selected electronic journals.
Secure, dedicated Oracle server platforms
- Allows creation of proprietary databases
- SQL programming capability
Work directly with molecular modeling provider
- Former head of computational chemistry at Novartis

Experimental Data Preparation

Symyx electronic notebook software allows rapid creation of experimental procedures in PDF form directly from the notebook.
Facile patent preparation.
Consistent notebook format from scientist to scientist.
NMR HPLC, MS, and IR, analytical data generated in PDF form and incorporated into notebook

Our Laboratories

Over 20,000 sq ft of lab space.
Custom designed medicinal chemistry research facility with open lab plan
Designed to eliminate exposure (zero-exposure) to scientists. 2 Chemists share 26 linear feet of hood space

Working with Clients

CDA or MSA executed prior to start of work
Review RFP and provide you with cost, timetable, decision points, critical issues, options
- Provide each RFP with the attention it deserves
- Reasonable yet aggressive timelines
Quotes on project basis or FTE basis
- Complexity of the chemistry
- Precedence of the chemistry
- SAR, IP enabling projects on FTE only
- FTE available on short-term basis

Kalexsyn is Growing and Stable

Financially stable
100% equity owned by CEO & CSO
Operating from a new state-of-the-art custom designed laboratory facility. Broad customer base
- 25% Europe, 75% USA
- Projects carried out for more than 87 pharmaceutical customers.
Currently recruiting for new scientists in 2010.

Our Strategic Partners (click on name to visit Website)