Kalexsyn, Inc: your science deserves the best scientists

Preclinical Capabilities Pharmacology

About Pharmoptima, Inc.

PharmOptima provides consulting and laboratory services to the biotech and pharmaceutical industries. As experts at drug discovery, PharmOptima helps clients create data packages to maximize the value of their intellectual property. Our clients save time and money by selecting the best drug candidates and identifying potential problems before costly animal safety studies and first in man testing. PharmOptima’s expertise includes:

In vivo ADME; establishing bioanalytical assays using HPLC/MS-MS and other methods, pharmacokinetic studies, PK/PD analyses, brain uptake, ocular PK, and GLP sample analysis.
In vitro ADME including microsomal and cellular metabolic profiling, isozyme characterization, p450 inhibition, and protein binding.
In vivo proof of concept testing to confirm drug delivery, efficacy, and tolerance plus the next studies required to optimize compounds.
Developing analytical assays for new compounds, validating these assays, and analyzing compounds in test articles and biological matrices.

PharmOptima’s Pharmacology/ADME scientists are knowledgeable in the requirements for successful drug discovery and registration with broad experience in drug discovery. With experts in biochemistry/high throughput screening, in vivo pharmacology, and ADME, PharmOptima is able to function as a Drug Discovery/Development Program Project Team. This Project Team approach provides our clients with multidisciplinary input to solve their R&D problems. PharmOptima’s staff scientists average over 20 years experience in drug discovery. This level of experience benefits our clients by yielding carefully designed and executed studies, generating the data required to move your IP up the value chain in a timely manner. For further information contact: Michael DeGraaf, Sales and Marketing, 6710 Quality Way, Portage, MI, 49002, Phone 269-492-3878, Fax 269-329-4390, E-mail medegraaf@pharmoptima.com.