Research Capabilities 
In Vitro Toxicology Services
About CeeTox, Inc.
CeeTox, Inc. provides a unique and robust in vitro toxicity screening approach designed to improve the drug discovery process. We have developed a proprietary algorithm that incorporates multiple- endpoint analysis, dose-response profiles, Pgp interaction, solubility, metabolic stability, and in vivo validation to provide an estimate of the sustained blood concentration in a rat 14-day repeat dose study where toxicity would first be expected to occur. We can improve the efficiency of early discovery research by providing data that allows teams to optimize safety and drug attributes simultaneously. The result is a reduced development time, a higher probability of success in preclinical animal testing and safer drugs. We provide a high throughput screening that rank orders large numbers of “hits” based on toxicity. We combine the results of 9 different biochemical assays to predict the point at which toxicity will first occur in vivo and give detailed information on sub-cellular sites of toxicity, all designed to expedite the lead optimization process. We provide in vitro assays that evaluate CYP enzyme induction, metabolic activation and CYP inhibition to evaluate the drug-drug interaction potential of a compound. We also evaluate cardiotoxicity, lipidosis and endocrine interactions and we assess anti-tumor drug candidates.copyright © 2008. Kalexsyn, Inc.
